14,15-EET Maintains Mitochondrial Homeostasis to Inhibit Neuronal Pyroptosis After Ischemic Stroke
14,15-EET regulates mitochondrial homeostasis to inhibit neuronal pyroptosis, thereby promoting the recovery of neurological function in mice after cerebral ischemia-reperfusion. These results provide new ideas for maintaining mitochondrial homeostasis and inhibiting neuronal pyroptosis after cerebral ischemia-reperfusion.
Authors
- Xinrui Lv (ORCID: https://orcid.org/0000-0003-0263-5715)
- Lai Wang (ORCID: https://orcid.org/0000-0002-3323-7210)
- Xiaohui Li (ORCID: https://orcid.org/0000-0003-3179-6585)
- Yanming Wang (ORCID: https://orcid.org/0000-0002-0710-043X)
- Zhen Li (ORCID: https://orcid.org/0009-0001-5712-8721)
- Yibo Zhang (ORCID: https://orcid.org/0000-0002-3502-9933)
- Yunxia Li (ORCID: https://orcid.org/0000-0003-1307-4335)
- Yi Wang (ORCID: https://orcid.org/0000-0001-8042-5970)
- Huixia Geng
- Yanshuo Zhang
- Chunting Ye (ORCID: https://orcid.org/0000-0002-1076-0850)
- Jing Tang (ORCID: https://orcid.org/0000-0003-3100-1842)
Institutions
- Henan University (CN)
- Kaifeng University (CN)
- First Affiliated Hospital of Henan University of Traditional Chinese Medicine (CN)
- Center for Clinical Research (United States) (US)
- First Affiliated Hospital of Henan University (CN)
Publication Details
- Journal
- Stroke
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1161/strokeaha.124.049143
- Citations
- 6
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 4.84