Network Pharmacology, Molecular Docking, and in vitro Experiments Reveal the Role and Mechanism of Tanshinone IIA in Colorectal Cancer Treatment Through the PI3K/AKT Pathway
Network pharmacology, molecular docking, and in vitro validation confirmed that Tan-IIA contributes to CRC treatment through the PI3K/AKT pathway, providing theoretical and experimental foundations for its potential clinical application.
Authors
- Bin Yu (ORCID: https://orcid.org/0000-0002-1258-4168)
- C Yang
- Jingwen Jiang (ORCID: https://orcid.org/0009-0006-9768-0314)
- Jin‐Peng Sun (ORCID: https://orcid.org/0000-0003-3572-1580)
- Jiacheng Song (ORCID: https://orcid.org/0000-0003-3576-9605)
- Shanpeng Wang (ORCID: https://orcid.org/0000-0003-2166-0043)
- Min Sun
- Xinmeng Qi
- Lijie Wang (ORCID: https://orcid.org/0009-0001-6262-9408)
Institutions
- Jining Medical University (CN)
Publication Details
- Journal
- Drug Design Development and Therapy
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/dddt.s492033
- Citations
- 4
- Primary Topic
- Traditional Chinese Medicine Analysis
- Type
- article
- Field-Weighted Citation Impact
- 9.53