Asymmetric synthesis of C–N axially chiral carbazoles <i>via</i> axial-to-axial chirality transfer
C-N axially chiral carbazole derivatives were synthesised by an intramolecular Buchwald-Hartwig amination starting from C-C axially chiral biaryls utilising an axial-to-axial chirality transfer with enantiospecificities up to 91%. The mechanism of the chirality transfer was investigated <i>via</i> DFT calculations.
Authors
- Birgit Henßen
- Martin Breugst (ORCID: https://orcid.org/0000-0003-0950-8858)
- Sebastian Myllek (ORCID: https://orcid.org/0000-0002-0538-4950)
- Philipp Neudecker (ORCID: https://orcid.org/0000-0002-0557-966X)
- Moritz K. T. Klischan (ORCID: https://orcid.org/0000-0002-3772-6556)
- Jörg Pietruszka (ORCID: https://orcid.org/0000-0002-9819-889X)
- Philip Lencer
Institutions
- Forschungszentrum Jülich (DE)
- Chemnitz University of Technology (DE)
- Heinrich Heine University Düsseldorf (DE)
Publication Details
- Journal
- Organic & Biomolecular Chemistry
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5ob00587f
- Citations
- 1
- Primary Topic
- Axial and Atropisomeric Chirality Synthesis
- Type
- article
- Field-Weighted Citation Impact
- 0.94