Hypothermic machine perfusion prevents hyperacute graft loss in pig-to-primate kidney xenotransplantation after 5-hours of cold Ischemia
Porcine kidneys are highly sensitive to ischemia-reperfusion injury after cold preservation across xenogeneic barriers. Routine SCS leads to early graft failure, while HMP mitigates ischemic injury and may enable successful clinical XTx despite prolonged CIT.
Authors
- Mitsuhiro Sekijima
- Hayato Iwase (ORCID: https://orcid.org/0000-0001-8499-373X)
- Wei‐Li Chen (ORCID: https://orcid.org/0000-0002-1538-2414)
- Alexander C. Schulick (ORCID: https://orcid.org/0000-0001-9275-6267)
- Andrew MacGregor Cameron (ORCID: https://orcid.org/0000-0002-5810-2398)
- Adam Luo (ORCID: https://orcid.org/0000-0002-3421-6913)
- Daniel Warren (ORCID: https://orcid.org/0000-0002-1370-466X)
- Yu Hisadome (ORCID: https://orcid.org/0000-0003-4849-7936)
- Daniel Eisenson (ORCID: https://orcid.org/0000-0003-3868-0403)
- Hisashi Sahara (ORCID: https://orcid.org/0000-0002-6455-0541)
- Michelle Santillan (ORCID: https://orcid.org/0009-0005-9942-6240)
- Eugene Shenderov (ORCID: https://orcid.org/0000-0001-9886-8542)
- Kelly Casella
- Kazuhiko Yamada (ORCID: https://orcid.org/0000-0002-0510-5843)
- Du Gu
Institutions
- Kagoshima University (JP)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
Publication Details
- Journal
- Communications Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1038/s43856-025-00842-6
- Citations
- 1
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- National Institutes of Health