Irisin mitigates osteoporotic-associated bone loss and gut dysbiosis in ovariectomized mice by modulating microbiota, metabolites, and intestinal barrier integrity
Irisin mitigates osteoporotic bone defects by enhancing bone formation, restoring intestinal barrier integrity, modulating gut microbiota composition, and influencing fecal metabolites. These preclinical findings highlight irisin's potential to mitigate osteoporosis via the gut-bone axis.
Authors
- Huimin Deng (ORCID: https://orcid.org/0000-0002-6228-5764)
- Xiaofeng Wang (ORCID: https://orcid.org/0000-0002-7476-2206)
- Zhihui Zhang (ORCID: https://orcid.org/0000-0002-6081-3236)
- Hongbo Wu
- Yiran Wang (ORCID: https://orcid.org/0000-0002-9062-4751)
- Zhang Zhiwen (ORCID: https://orcid.org/0000-0001-8137-9574)
Institutions
- Huizhou Central People's Hospital (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-04-16
- DOI
- https://doi.org/10.1186/s12891-025-08622-y
- Citations
- 1
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 1.16