Genome-wide nucleosome footprints of plasma cfDNA predict preterm birth: A case-control study
In summary, PTerm demonstrated high accuracy in predicting preterm birth. Additionally, it can be utilized with current non-invasive prenatal test data without changing its procedures or increasing detection cost, making it easily adaptable for preclinical tests.
Authors
- Zhiwei Guo (ORCID: https://orcid.org/0000-0003-0375-0838)
- Bo‐Wei Han
- Ke Wang (ORCID: https://orcid.org/0000-0002-5305-6791)
- Guojun Ouyang
- Richard Beatson (ORCID: https://orcid.org/0000-0002-0411-932X)
- Xuexi Yang (ORCID: https://orcid.org/0000-0002-3513-6501)
- Jinhai Deng (ORCID: https://orcid.org/0000-0002-2899-5332)
- Xiang-Ming Zhai
- Kun Li (ORCID: https://orcid.org/0000-0002-8244-9404)
- Min Zhang (ORCID: https://orcid.org/0000-0002-4467-618X)
- Fang Yang (ORCID: https://orcid.org/0000-0002-2708-3913)
- Xiang Huang (ORCID: https://orcid.org/0000-0002-4456-5893)
- Jia Tang (ORCID: https://orcid.org/0000-0002-2000-934X)
- Yingsong Wu (ORCID: https://orcid.org/0000-0002-3734-702X)
- Xu Yang (ORCID: https://orcid.org/0000-0003-2242-670X)
- Liangping Luo (ORCID: https://orcid.org/0000-0002-7312-5782)
- Haihong Shi
- Jiayu Tan
Institutions
- Jinan University (CN)
- Baylor College of Medicine (US)
- King's College London (GB)
- London Cancer (GB)
- Guangzhou Experimental Station (CN)
- Foshan Maternity and Child Health Care Hospital (CN)
- Nanfang Hospital (CN)
- Guangzhou First People's Hospital (CN)
- Zhujiang Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1371/journal.pmed.1004571
- Citations
- 7
- Primary Topic
- Preterm Birth and Chorioamnionitis
- Type
- article
- Field-Weighted Citation Impact
- 9.48
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province