Analysis of cases of side effects of medicines used in geriatric practice

The main purpose of using medicinal products is to achieve their positive therapeutic effect, however, medicines can be the cause of risks. An important task facing medical professionals, marceting auterisation holders (applicants) is to analyze cases of adverse drug reactions or ineffectiveness of medicines, in particular, in the direction of identifying and assessing risk factors contributing to their occurrence, as well as risk groups. To analyze card reports on cases of adverse drug reactions of the medicines Xavron, solution for injection (hereinafter – Xavron), Neurocytin ®, solution for infusions (hereinafter – Neurocytin), Tivorel, solution for infusions (hereinafter - Tivorel), Tivortin®, solution for infusions (hereinafter – Tivortin) of the Limited Liability Company «YURiYA-PHARM» in order to assess the predictability, severity, frequency of occurrence, type and causes of occurrence, as possible risk factors. The following methods were used in the work: assessment of spontaneous reports of adverse drug reactions, expert assessments, bibliosemantic, analytical, statistical. The appropriateness of prescribing medicines is assessed by weighing the benefits of their use and the risks inherent in them, primarily adverse drug reactions. Various factors contribute to the occurrence of risks, knowledge of which allows us to predict, reduce the likelihood of developing risks, develop and implement measures to minimize risks. Knowledge of risk groups is important in terms of reducing the impact of risks on the benefits of using medicines. This article presents theoretical generalizations regarding risks, as well as the results of our own analysis of individual cases on the safety of the medicines Xavron, Neurocytin, Tivorel and Tivortin in a gerontological cohort of patients in the direction of identifying risk groups and factors. The results of the work have shown that advanced age and female gender may be risk factors for adverse drug reactions to the medicines Xavron, Neurocytin, Tivorel and Tivortin. However, the duration, predictability, severity, type and frequency of adverse reactions to the indicated drugs are not considered risk factors for adverse reactions to these medicines.