Dynamics of Mutant Hematopoietic Progenitor Cells Are Not Associated with Clinical Outcomes in Multiple Myeloma
SPMs that develop in patients with multiple myeloma have a deleterious impact on survival. Patients with CH may be at risk of developing SPMs, which could potentially be avoided through individualized treatment. However, our results suggest that screening for CH at diagnosis has limited utility.
Authors
- Iria Vázquez (ORCID: https://orcid.org/0000-0003-0027-6384)
- Sarai Sarvide (ORCID: https://orcid.org/0000-0003-3528-9329)
- Laura Rosiñol (ORCID: https://orcid.org/0000-0002-2534-9239)
- Felipe de Arriba (ORCID: https://orcid.org/0000-0002-4451-1318)
- Juan José Lahuerta (ORCID: https://orcid.org/0000-0002-3393-9570)
- Jesús F. San Miguel (ORCID: https://orcid.org/0000-0002-9183-4857)
- Catarina Maia (ORCID: https://orcid.org/0000-0003-3546-1782)
- María‐Victoria Mateos (ORCID: https://orcid.org/0000-0003-2390-1218)
- Diego Alignani (ORCID: https://orcid.org/0000-0003-0241-1375)
- Joan Bladé (ORCID: https://orcid.org/0000-0002-4563-3405)
- Irache Erdozain
- Joaquín Martínez‐López (ORCID: https://orcid.org/0000-0001-7908-0063)
- Marta Sonia González (ORCID: https://orcid.org/0000-0001-5494-9009)
- Cristina Pérez (ORCID: https://orcid.org/0000-0003-3586-2666)
- María José Larráyoz (ORCID: https://orcid.org/0000-0003-0667-1959)
- María‐Teresa Cedena (ORCID: https://orcid.org/0000-0001-5851-3720)
- Noemí Puig (ORCID: https://orcid.org/0000-0001-7535-3861)
- Camila Guerrero (ORCID: https://orcid.org/0000-0003-1395-5140)
- Albert Oriol (ORCID: https://orcid.org/0000-0001-6804-2221)
- Bruno Paiva (ORCID: https://orcid.org/0000-0003-1977-3815)
- Valentín Cabañas (ORCID: https://orcid.org/0000-0002-6248-2549)
- Ana Pilar González (ORCID: https://orcid.org/0000-0002-0565-9133)
- José M. Moraleda (ORCID: https://orcid.org/0000-0001-9080-1466)
- Luis Palomera (ORCID: https://orcid.org/0000-0003-0359-7191)
- Marı́a José Calasanz (ORCID: https://orcid.org/0000-0002-0374-3008)
- Oihane Churruca
- Jesús Martín (ORCID: https://orcid.org/0000-0003-4250-4824)
- Rafael Ríos (ORCID: https://orcid.org/0000-0001-8193-1402)
- Amagoia Mañú
- Natalia Gordillo
Institutions
- Hospital General Universitario Morales Meseguer (ES)
- Hospital Universitario 12 De Octubre (ES)
- Hospital Clínic de Barcelona (ES)
- Hospital Universitario Virgen de las Nieves (ES)
- Hospital Universitario Central de Asturias (ES)
- Clinica Universidad de Navarra (ES)
- Hospital Clínico Universitario Lozano Blesa (ES)
- Centro de Investigación del Cáncer (ES)
- Complexo Hospitalario Universitario A Coruña (ES)
- Hospital Universitario Virgen de la Arrixaca (ES)
- Hospital Universitario Virgen del Rocío (ES)
- Hospital Universitari Germans Trias i Pujol (ES)
Publication Details
- Journal
- Blood Cancer Discovery
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1158/2643-3230.bcd-24-0274
- Citations
- 1
- Primary Topic
- Multiple Myeloma Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- International Myeloma Foundation
- Cancer Research UK
- European Commission
- Fundación Científica Asociación Española Contra el Cáncer
- Fondazione Regionale per la Ricerca Biomedica
- Instituto de Salud Carlos III
- HORIZON EUROPE European Research Council