Generation of an induced pluripotent stem cell (iPSC) line (INNDSUi0010-A) from a patient with Anti-MDA5 antibody-positive dermatomyositis
Anti-melanoma differentiation-associated protein 5 (MDA5) antibody-positive dermatomyositis (MDA5-DM) is a subtype of dermatomyositis, potentially triggered by viral infection (Lu et al., 2024). We generated and characterized a human induced pluripotent stem cell (hiPSC) line from skin fibroblasts of a patient with MDA5-DM. Their pluripotency was demonstrated by the expression of multiple pluripotency markers on the RNA and protein levels, as well as their ability to differentiate into all three germ layers.
Authors
- Kai Shao (ORCID: https://orcid.org/0000-0003-1563-5722)
- Chuanzhu Yan (ORCID: https://orcid.org/0000-0002-2191-5184)
- Hongxu Wang (ORCID: https://orcid.org/0000-0001-5248-4578)
- Ying Hou (ORCID: https://orcid.org/0000-0002-5366-9934)
- Xiaotian Ma
- G. Zhang (ORCID: https://orcid.org/0009-0003-5360-5660)
- Qingsong Fu
- Chen Zhang (ORCID: https://orcid.org/0000-0002-0475-0584)
- Jianing Li (ORCID: https://orcid.org/0000-0002-0143-8894)
- Ping Sun (ORCID: https://orcid.org/0000-0003-4607-0592)
- Fengyi Zhang (ORCID: https://orcid.org/0000-0002-2398-8176)
- Fuchen Liu
- Tingjun Dai (ORCID: https://orcid.org/0000-0003-4928-0421)
- Bing Zhao (ORCID: https://orcid.org/0000-0002-1565-685X)
- Didi Shan
- Yu Wang (ORCID: https://orcid.org/0000-0001-8697-2940)
- Shaoshuai Liang
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Stem Cell Research
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.scr.2025.103714
- Citations
- 1
- Primary Topic
- Inflammatory Myopathies and Dermatomyositis
- Type
- article
- Field-Weighted Citation Impact
- 1.35