Antidepressant Effects of Nitrous Oxide in Major Depressive Disorder: A Phase 2b Randomized Clinical Trial
In this study, we confirmed that nitrous oxide has likely beneficial antidepressant effects in people with MDD.
Authors
- Jayashri Kulkarni (ORCID: https://orcid.org/0000-0002-3875-5623)
- Peter Nägele (ORCID: https://orcid.org/0000-0001-8369-3858)
- Paul Stewart Myles (ORCID: https://orcid.org/0000-0002-3324-5456)
- Robert D. Gibbons (ORCID: https://orcid.org/0000-0002-6463-2280)
- Jessica Kasza (ORCID: https://orcid.org/0000-0002-8940-0136)
- Alisa Turbić (ORCID: https://orcid.org/0000-0002-9703-2484)
- Charles R. Conway (ORCID: https://orcid.org/0000-0001-6849-9416)
- Verna M. Aykanat (ORCID: https://orcid.org/0000-0002-3936-6128)
- Carolyn Deng (ORCID: https://orcid.org/0000-0002-1186-6622)
- Royce Lee (ORCID: https://orcid.org/0000-0003-3095-860X)
- Sophie Wallace (ORCID: https://orcid.org/0000-0001-6120-4881)
- Frank Brown
Institutions
- The University of Melbourne (AU)
- Washington University in St. Louis (US)
- The Alfred Hospital (AU)
- University of Chicago (US)
- Monash Alfred Psychiatry Research centre (AU)
- Monash University (AU)
Publication Details
- Journal
- Biological Psychiatry Global Open Science
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.bpsgos.2025.100504
- Citations
- 4
- Primary Topic
- Treatment of Major Depression
- Type
- article
- Field-Weighted Citation Impact
- 5.58
Funders
- Australian and New Zealand College of Anaesthetists
- National Health and Medical Research Council