Islet Autoantibodies and Their Association With β-Cell Function and Diabetes Measures in Children With Acute Recurrent and Chronic Pancreatitis
In children with ARP or CP, Ab+ was associated with higher risk of diabetes/diabetes development and shorter time to diabetes development, suggesting that islet Ab+ is associated with β-cell dysfunction in this patient cohort. Islet Ab+ was also associated with higher HbA1c and lower C-peptide levels. Future studies are needed to validate the role of islet Ab positivity in pancreatitis.
Authors
- Melena D. Bellin (ORCID: https://orcid.org/0000-0002-7324-4837)
- Jonathan Tatum (ORCID: https://orcid.org/0009-0000-0029-940X)
- Deborah A. Elder (ORCID: https://orcid.org/0000-0002-6417-3619)
- Lindsey Hornung (ORCID: https://orcid.org/0000-0003-0722-7307)
- Lee A. Denson (ORCID: https://orcid.org/0000-0001-8045-7198)
- AMY SANGHAVI SHAH (ORCID: https://orcid.org/0000-0001-7297-139X)
- Maisam Abu‐El‐Haija (ORCID: https://orcid.org/0000-0002-8968-7851)
- Sarah Swauger (ORCID: https://orcid.org/0000-0001-7298-4959)
- Siobhan Tellez (ORCID: https://orcid.org/0000-0002-3631-0313)
- Gila Ginzburg
Institutions
- Children's Hospital of Wisconsin (US)
- Cincinnati Children's Hospital Medical Center (US)
- Medical College of Wisconsin (US)
- University of Minnesota Medical Center (US)
- University of Cincinnati Medical Center (US)
Publication Details
- Journal
- Diabetes Care
- Published
- 2025-04-15
- DOI
- https://doi.org/10.2337/dc24-2672
- Citations
- 2
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63
Funders
- National Institutes of Health