Mechanisms of Neuronal Differentiation and Notch Signaling as a Potential Therapeutic Target in Olfactory Dysfunction of Allergic Rhinitis
Our research indicates that impaired differentiation of olfactory neurons may contribute to the underlying causes of olfactory dysfunction in AR. Additionally, inhibiting the Notch signaling pathway promotes the maturation of the olfactory epithelium and improves olfactory dysfunction in AR mice, offering potential therapeutic strategies for olfactory disorders in AR.
Authors
- Changhua Wu (ORCID: https://orcid.org/0000-0001-6206-557X)
- Xinyi Ma
- Xin Feng (ORCID: https://orcid.org/0000-0001-8089-4005)
- Fangying Liu
- Xinyu Xie (ORCID: https://orcid.org/0000-0001-5039-3349)
- Ye Yuan (ORCID: https://orcid.org/0000-0003-1144-2341)
- Ping Ye (ORCID: https://orcid.org/0000-0003-1408-8704)
- Chen Duan (ORCID: https://orcid.org/0000-0002-6223-9792)
- Xiaojun Zhang (ORCID: https://orcid.org/0000-0003-4731-9679)
Institutions
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/jir.s504050
- Primary Topic
- Olfactory and Sensory Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00