Mapping the temporal transcriptomic signature of a viral pathogen through CAGE and nanopore sequencing
The shifting patterns in transcript isoforms and overlaps suggest a sophisticated regulatory network that enables EHV-1 to precisely modulate gene expression throughout its replication cycle. The presence of multiple isoforms per gene indicates that the virus can adapt to different stages of infection by producing a variety of transcripts. This likely enhances its genomic efficiency and allows it to respond more effectively to the host's environment.
Authors
- Dóra Tombácz (ORCID: https://orcid.org/0000-0001-5520-2978)
- Ákos Dörmő (ORCID: https://orcid.org/0000-0003-1860-1122)
- Ádám Fülöp (ORCID: https://orcid.org/0000-0002-3795-2748)
- Gábor Gulyás (ORCID: https://orcid.org/0000-0002-7465-7932)
- Zsolt Csabai (ORCID: https://orcid.org/0000-0003-0031-0116)
- Zsolt Boldogkői (ORCID: https://orcid.org/0000-0003-1184-7293)
- Gábor Torma (ORCID: https://orcid.org/0000-0003-3241-0955)
- Balázs Kakuk (ORCID: https://orcid.org/0000-0002-4314-5707)
Institutions
- University of Szeged (HU)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1371/journal.pone.0320439
- Citations
- 1
- Primary Topic
- Herpesvirus Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.35
Funders
- Nemzeti Kutatási Fejlesztési és Innovációs Hivatal
- National Research, Development and Innovation Office