First-trimester exposure to macrolides and risk of major congenital malformations compared with amoxicillin: A French nationwide cohort study
The findings indicate that macrolide exposure during the first trimester is not strongly associated with an increased risk for most individual MCMs, which is reassuring. However, an increased risk of spina bifida and syndactyly remains possible. Future studies are required to investigate these observations further as evidence continues to grow.
Authors
- Jérôme Drouin (ORCID: https://orcid.org/0000-0003-2017-7041)
- Anh Tran (ORCID: https://orcid.org/0000-0003-3541-5524)
- Rosemary Dray‐Spira (ORCID: https://orcid.org/0000-0001-7646-3667)
- Mahmoud Zureik (ORCID: https://orcid.org/0000-0002-8393-4217)
- Sarah Tubiana (ORCID: https://orcid.org/0000-0002-6526-6403)
- Alain Weill (ORCID: https://orcid.org/0000-0001-8687-9092)
- Jeanne Sibiude (ORCID: https://orcid.org/0000-0002-6449-827X)
- Lise Marty (ORCID: https://orcid.org/0000-0001-8496-5886)
- Xavier Duval
- Sara Miranda (ORCID: https://orcid.org/0009-0009-4163-0918)
Institutions
- Inserm (FR)
- Université Paris Cité (FR)
- Sorbonne Université (FR)
- Hôpital Louis-Mourier (FR)
- Université Sorbonne Paris Nord (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail (FR)
- Hôpital Bichat-Claude-Bernard (FR)
- Centre d'Investigation Clinique - Innovation Technologique (FR)
- Centre d'Investigation Clinique Bichat
Publication Details
- Journal
- PLoS Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1371/journal.pmed.1004576
- Citations
- 4
- Primary Topic
- Pregnancy and Medication Impact
- Type
- article
- Field-Weighted Citation Impact
- 7.51