Spatially and temporally mismatched blood flow and neuronal activity by high-intensity intracortical microstimulation
Our study offers new insights into ICMS-associated neuronal and vascular physiology with potentially critical implications towards the optimal design of ICMS in neuroprosthetic therapies: low intensities preserve NVC; high intensities disrupt NVC responses and potentially precipitate blood supply deficits.
Authors
- Krzysztof Kucharz (ORCID: https://orcid.org/0000-0002-6852-5300)
- Kayeon Kim (ORCID: https://orcid.org/0000-0002-4565-9429)
- Anpan Han (ORCID: https://orcid.org/0000-0001-6878-9886)
- Changsi Cai (ORCID: https://orcid.org/0000-0002-7001-610X)
- Lechan Tao (ORCID: https://orcid.org/0009-0006-0410-6592)
- Dmitry D. Postnov (ORCID: https://orcid.org/0000-0002-9708-8453)
- Antonis Asiminas (ORCID: https://orcid.org/0000-0002-6492-0960)
- Barbara Lykke Lind (ORCID: https://orcid.org/0000-0003-0027-5226)
- Xiao Zhang (ORCID: https://orcid.org/0000-0002-9101-3565)
- Alexandra Katherine Isis Yonza (ORCID: https://orcid.org/0009-0008-9720-4961)
- Victor Sonego (ORCID: https://orcid.org/0009-0009-5831-5543)
Institutions
- University of Copenhagen (DK)
- Aarhus University (DK)
- Technical University of Denmark (DK)
Publication Details
- Journal
- Brain stimulation
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.brs.2025.04.015
- Primary Topic
- Neuroscience and Neural Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Sundhed og Sygdom, Det Frie Forskningsråd
- Lundbeckfonden
- Novo Nordisk
- Nordea-fonden
- Helsefonden
- Novo Nordisk Fonden
- Oda og Hans Svenningsens Fond
- H. Lundbeck A/S
- Medical Research Council