Qing'e Pill rectifies bone homeostasis imbalance in diabetic osteoporosis via the AGE/RAGE pathway: A network pharmacology analysis and multi-omics validation
QEP enhance osteogenesis and angiogenesis via the AGE/RAGE signaling pathway, offering anti-inflammatory, hypoglycemic, and anti-osteoporotic effects. These results support the potential clinical application of QEP in managing diabetic osteoporosis.
Authors
- Xianzuo Zhang (ORCID: https://orcid.org/0000-0002-6432-7745)
- Junchen Zhu (ORCID: https://orcid.org/0009-0002-1587-8185)
- Wanbo Zhu (ORCID: https://orcid.org/0000-0003-3457-3432)
- Siming Zhang
- Yingjie Wang (ORCID: https://orcid.org/0000-0001-8769-1948)
- Yuan Chen (ORCID: https://orcid.org/0000-0001-9059-3839)
- Yanling Zhou (ORCID: https://orcid.org/0000-0003-3605-8231)
- Yang Yao (ORCID: https://orcid.org/0000-0003-4183-1268)
Institutions
- University of Science and Technology of China (CN)
- Anhui Medical University (CN)
- Anhui University of Traditional Chinese Medicine (CN)
- Shanghai Sixth People's Hospital (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
Publication Details
- Journal
- Journal of Ethnopharmacology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jep.2025.119816
- Citations
- 4
- Primary Topic
- Bone Metabolism and Diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.22
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Scientific Research Foundation of Education Department of Anhui Province of China
- Anhui Provincial Key Research and Development Plan