Maternal Tmprss6 is required for hepcidin suppression and fetal health
The antenatal role of the hepcidin-regulating protease Tmprss6 has never been elucidated because knockout dams are infertile. Using an in vivo knockdown approach, we confirm Tmprsss6 is critical for hepcidin suppression in pregnancy, and Tmprss6 inhibition drives deleterious fetal outcomes.
Authors
- Louise M. Randall (ORCID: https://orcid.org/0009-0002-0391-1080)
- Anne Pettikiriarachchi
- Cavan Bennett (ORCID: https://orcid.org/0000-0002-9796-9381)
- Katherine Fielding (ORCID: https://orcid.org/0000-0002-6524-3754)
- Ricardo Ataíde (ORCID: https://orcid.org/0000-0002-1014-0432)
- Rebecca Harding (ORCID: https://orcid.org/0000-0003-4267-716X)
- Sant‐Rayn Pasricha (ORCID: https://orcid.org/0000-0002-5502-0434)
- Ute Schaeper (ORCID: https://orcid.org/0000-0003-2556-8391)
- Alistair R. D. McLean (ORCID: https://orcid.org/0000-0003-3449-7142)
- Alberto Martínez (ORCID: https://orcid.org/0000-0001-9564-8667)
- N. F. Jones
Institutions
- Walter and Eliza Hall Institute of Medical Research (AU)
- Silence Therapeutics (Germany) (DE)
- Silence Therapeutics (United Kingdom) (GB)
Publication Details
- Journal
- Blood
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1182/blood.2024027563
- Citations
- 1
- Primary Topic
- Cancer-related molecular mechanisms research
- Type
- article
- Field-Weighted Citation Impact
- 0.94
Funders
- State Government of Victoria
- Silence Therapeutics
- National Health and Medical Research Council