Identification of autoantibodies targeting citrullinated CLEC12A in rheumatoid arthritis patients
This is the first report of seropositivity towards citrullinated CLEC12A in RA patients. A validation cohort will confirm our findings and identify additional correlations between these autoantibodies and clinical parameters. Citrullination may be a mechanism through which CLEC12A's inhibitory function is altered to exacerbate inflammation in RA. Identifying citrullinated neoantigens advances our understanding of the diverse molecular mechanisms that contribute to RA pathogenesis.
Authors
- Ewa Cairns (ORCID: https://orcid.org/0000-0003-2748-3076)
- Lillian Barra
- Guillaume Paré (ORCID: https://orcid.org/0000-0002-6795-4760)
- Mathias Mangion
- Halim Maaroufi (ORCID: https://orcid.org/0000-0002-3026-5339)
- Sheri Saunders
- Alain Garnier
- Maria J. Fernandes (ORCID: https://orcid.org/0000-0002-3973-025X)
Institutions
- Western University (CA)
- Centre hospitalier universitaire de Québec (CA)
- Université Laval (CA)
Publication Details
- Journal
- Journal of Translational Autoimmunity
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jtauto.2025.100287
- Citations
- 2
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 2.72