Dhātu Siddhānta and its clinical implications in tissue regeneration

The Dhātu Siddhānta forms one of the essential pillars of Ayurvedic physiology and pathology. Derived from the root concept "धृ धारणे" (to sustain), dhātus refer to the seven fundamental tissues that provide structural and functional support to the human body. These include Rasa (plasma/lymph), Rakta (blood), Māṃsa (muscle), Meda (fat), Asthi (bone), Majjā (marrow), and Śukra (reproductive tissue). Each dhātu nourishes the next in a sequential chain, emphasizing the importance of proper metabolism and transformation (dhātu-pāka). This paper discusses the philosophical origin of dhātus, their physiological relevance, the process of dhātu formation, and the therapeutic implications of Dhātu Siddhānta in modern clinical contexts such as tissue regeneration, wound healing, and chronic degenerative conditions.