10-kHz High-Frequency Spinal Cord Stimulation Significantly Reduces Proinflammatory Cytokines and Distinct Populations of T Lymphocytes in Patients With Persistent Spinal Pain Syndrome Type 2
These changes suggest that PSPS-T2 is a chronic inflammatory condition characterized by cytotoxic and exhausted immune cell populations. The resolution of this inflammation by distinct immune cell populations induced by SCS may contribute to pain relief, and specific populations, such as T<sub>H</sub>17 and NKT cells, may represent useful biomarkers of treatment effectiveness.
Authors
- Luke A. Henderson (ORCID: https://orcid.org/0000-0002-1026-0151)
- Rebecca V Robertson
- Paul J. Austin (ORCID: https://orcid.org/0000-0001-5253-6876)
- Alister Ramachandran
- Peng An (ORCID: https://orcid.org/0000-0002-7966-0751)
- J A O'Brien (ORCID: https://orcid.org/0000-0001-5305-4350)
- Stefanie S Kogias
- Fernando A Tinoco-Mendoza
Institutions
- Westmead Hospital (AU)
- Neuroscience Research Australia (AU)
Publication Details
- Journal
- Neuromodulation Technology at the Neural Interface
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1016/j.neurom.2025.02.010
- Citations
- 5
- Primary Topic
- Pain Management and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 10.95
Funders
- Australian and New Zealand College of Anaesthetists
- Neil and Norma Hill Foundation