Functional evaluation of saclipins A and B derived from the edible cyanobacterium <i>Aphanothece sacrum</i>: New bioactivities for anti-wrinkle and anti-hypertension

Saclipin A and saclipin B are bioactive oxylipin compounds derived from an edible cyanobacterium, Aphanothece sacrum. Saclipins have been shown to have potent anti-aging properties, including antioxidative, antiglycative, anti-wrinkle, and skin-whitening activities. In this study, we demonstrate that the anti-collagenase and anti-hyaluronidase activities of saclipins are additional anti-wrinkle properties of these compounds. Furthermore, we reveal that saclipins exert angiotensin-converting enzyme (ACE) inhibitory activities, which can mitigate hypertension. These results suggest that saclipins are promising natural products with applications not only for skincare products but also as medical supplements.