Knock-in Kcnh2 rabbit model of long QT syndrome type-2, epilepsy, and sudden death
We developed the first genetic rabbit model of LQT2 that reproduces the cardiac and epileptic phenotypes seen in people with LQT2. Kcnh2<sup>(+/7bp-del)</sup> rabbits provide a valuable tool for future mechanistic studies, development of neurotherapeutics, and cardiac-safety testing.
Authors
- Louis T. Dang (ORCID: https://orcid.org/0000-0003-4853-4952)
- Ryan T. Gardner
- Katherine R. Keller (ORCID: https://orcid.org/0000-0002-7664-5652)
- Veronica Singh (ORCID: https://orcid.org/0009-0008-3335-6384)
- Julie Ziobro (ORCID: https://orcid.org/0000-0002-7250-7308)
- David S. Auerbach (ORCID: https://orcid.org/0000-0001-9198-3847)
- Kyle Wagner
- Nathan R. Tucker (ORCID: https://orcid.org/0000-0002-5071-4218)
- Justin M. Ryan (ORCID: https://orcid.org/0000-0001-6003-9706)
- Richard J.H. Wojcikiewicz (ORCID: https://orcid.org/0000-0001-8092-6417)
- L. Williams
- Jonathan D. Mohnkern
Institutions
- SUNY Upstate Medical University (US)
- University of Michigan (US)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1186/s12967-025-06382-w
- Citations
- 4
- Primary Topic
- Cardiac electrophysiology and arrhythmias
- Type
- article
- Field-Weighted Citation Impact
- 5.55
Funders
- American Heart Association
- American Epilepsy Society
- National Institute of Neurological Disorders and Stroke