Precancerous Cells Initiate Glioblastoma Evolution and Contribute to Intratumoral Heterogeneity
We identified mutation-harboring precancerous cells that emerge via oligodendrocyte progenitor cell fate specification and contribute to the evolution of GBM with intratumoral molecular heterogeneity. This single-cell atlas from the GBM mouse model and patients' tissues revealed distinct transitional states of precancerous cells and demonstrated step-wise acquisition of oncogenic programs during GBM progression. See related commentary by Lee and Suvà, p. 1312.
Authors
- Myeong-Heui Kim (ORCID: https://orcid.org/0000-0003-4306-3450)
- Keon Woo Kim (ORCID: https://orcid.org/0000-0002-1224-1501)
- Jung Won Park (ORCID: https://orcid.org/0000-0002-5300-3745)
- Jong Hee Chang (ORCID: https://orcid.org/0000-0003-1509-9800)
- Eui Hyun Kim (ORCID: https://orcid.org/0000-0002-2523-7122)
- Jihwan Yoo (ORCID: https://orcid.org/0000-0001-8746-1245)
- Do Hyeon Cha (ORCID: https://orcid.org/0000-0003-1005-7783)
- Seok‐Gu Kang (ORCID: https://orcid.org/0000-0001-5676-2037)
- Ja Hye Kim (ORCID: https://orcid.org/0000-0002-2477-5199)
- Jeong Ho Lee (ORCID: https://orcid.org/0000-0002-2299-630X)
- Hyun Jung Kim (ORCID: https://orcid.org/0000-0002-9520-1109)
- Yong‐Hee Kim (ORCID: https://orcid.org/0000-0003-2177-4876)
- Joo Ho Lee (ORCID: https://orcid.org/0000-0001-7248-3214)
- Yeon-Hee Lee
- Xue Li (ORCID: https://orcid.org/0009-0002-6873-5321)
- Ee Lin Lim
Institutions
- Seoul National University (KR)
- Korea Advanced Institute of Science and Technology (KR)
- Yonsei University (KR)
- Korea University (KR)
- Severance Hospital (KR)
- New Generation University College (ET)
- Seoul National University Hospital (KR)
- National University College (PR)
- Gangnam Severance Hospital (KR)
- Deargen (South Korea) (KR)
- Yonsei University Health System (KR)
- Korea University (JP)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1158/2159-8290.cd-24-0234
- Citations
- 9
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 14.63
Funders
- Korea Health Industry Development Institute
- National Research Foundation of Korea
- Korea Advanced Institute of Science and Technology
- College of Medicine, Korea University