Immunosenescence markers in T- and NK-cells according to the CD4/CD8 ratio in successfully treated people living with HIV
PLWH on successful ART display elevated immunosenescence markers, mainly on CD8+ T-cells. A CD4/CD8 cut-off value below 0.4 showed the strongest association with immune dysfunction, including NK+ cells. Such results could be useful for identifying patients requiring closer follow-up and screening for complications.
Authors
- Michel Ticchioni (ORCID: https://orcid.org/0000-0002-9949-0411)
- S. Addou (ORCID: https://orcid.org/0000-0002-5316-5752)
- David Chirio (ORCID: https://orcid.org/0000-0002-7186-2818)
- Michel Carlès (ORCID: https://orcid.org/0000-0001-5485-1511)
- Christian Pradier (ORCID: https://orcid.org/0000-0002-0676-6379)
- Roxane Fabre (ORCID: https://orcid.org/0000-0001-5670-1322)
- Matteo Vassallo (ORCID: https://orcid.org/0000-0002-3605-3871)
- Éric Cua
- Alissa Naqvi
- J. Durant
- Maeva Godemert
- Leslie Ameil
Institutions
- Université Côte d'Azur (FR)
- Centre Hospitalier Universitaire de Nice (FR)
- Centre Hospitalier de Cannes (FR)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fmed.2025.1562537
- Citations
- 3
- Primary Topic
- HIV Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 3.11