Down-regulation of miR-125b by HPV16 E6 might promote cervical cancer progression through TAZ/TEAD
HPV E6 promotes the malignant progression of cervical cancer cells by downregulating miR-125b, which targets TAZ, thus regulating the Hippo pathway. Consequently, miR-125b emerges as a promising therapeutic target for HPV-induced cervical cancer.
Authors
- Yong Ji (ORCID: https://orcid.org/0000-0002-1030-6105)
- Xiaoqiang Su
- Wenhao Wang (ORCID: https://orcid.org/0000-0002-6499-9779)
- Yongli Hou
- Lili Zhang (ORCID: https://orcid.org/0009-0009-6981-6167)
- Min Hao (ORCID: https://orcid.org/0000-0002-2631-0096)
- Keyan Cheng
- H. Wang (ORCID: https://orcid.org/0009-0001-2467-5331)
Institutions
- Shanxi Medical University (CN)
- Second Hospital of Shanxi Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fonc.2025.1444874
- Citations
- 3
- Primary Topic
- Hippo pathway signaling and YAP/TAZ
- Type
- article
- Field-Weighted Citation Impact
- 3.45
Funders
- Natural Science Foundation of Shanxi Province