The association of molecular classification with fertility-sparing treatment of atypical endometrial hyperplasia and endometrial cancer: a retrospective study

Molecular classification may be associated with hormone treatment response in patients with AEH, EC patients with POLEmut and p53wt had better progestin response, and those with MMRd and p53abn had the poorest response and the highest recurrence rate. Recurrence was common after CR, but close review is necessary. For further investigation of the role of molecular classification in fertility-sparing treatment of AEH/EC, larger prospective studies are necessary.