Variant pubertal development in Prader-Willi syndrome: early and slow progression of pubarche with normal age at gonadarche
Children with PWS, regardless of the genetic subtype and/or <i>MKRN3</i> status, had an early pubarche and normally timed gonadarche. Pubarche progression was slower. Advanced BA was significantly correlated with gonadarche.
Authors
- Jan Lebl
- Zdenĕk Šumnı́k (ORCID: https://orcid.org/0000-0002-6462-6462)
- Shenali Anne Amaratunga (ORCID: https://orcid.org/0000-0002-3388-5824)
- Marta Šnajderová (ORCID: https://orcid.org/0009-0005-4111-1270)
- Renata Pomahačová (ORCID: https://orcid.org/0000-0002-7952-1364)
- Barbora Obermannová (ORCID: https://orcid.org/0009-0002-5126-7349)
- Petra Dušátková (ORCID: https://orcid.org/0000-0002-8647-9088)
- Jiřina Zapletalová (ORCID: https://orcid.org/0000-0003-2333-5586)
- Stanislava Koloušková (ORCID: https://orcid.org/0009-0002-1352-3313)
- Aneta Kodytková (ORCID: https://orcid.org/0009-0007-9281-4376)
- Valerij Semjonov (ORCID: https://orcid.org/0009-0008-3966-7116)
- Štěpánka Průhová (ORCID: https://orcid.org/0000-0003-2076-115X)
Institutions
- Charles University (CZ)
- University Hospital in Motol (CZ)
- University Hospital Olomouc (CZ)
- Palacký University Olomouc (CZ)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fendo.2025.1527140
- Citations
- 3
- Primary Topic
- Genetic Syndromes and Imprinting
- Type
- article
- Field-Weighted Citation Impact
- 5.45