Obesity accelerates age-related memory deficits and alters white matter tract integrity in Ldlr-/-.Leiden mice
Ldlr-/-.Leiden mice show similar critical age-related changes in brain structure and function as observed in humans. In this mouse model, HFD feeding particularly trigger disturbances in brain blood perfusion and white matter tract integrity, which may underlie an accelerated cognitive decline in obesity.
Authors
- Joline Attema
- Maximilian Wiesmann (ORCID: https://orcid.org/0000-0002-1412-398X)
- Wim van Duyvenvoorde
- Martine C. Morrison (ORCID: https://orcid.org/0000-0003-4996-943X)
- Amanda J. Kiliaan (ORCID: https://orcid.org/0000-0002-2158-6210)
- Florine Seidel (ORCID: https://orcid.org/0000-0002-9948-3684)
- Robert Kleemann (ORCID: https://orcid.org/0000-0002-1350-0149)
- Jessica Snabel
- Ilse A.C. Arnoldussen (ORCID: https://orcid.org/0000-0002-7395-5284)
- Bram Geenen (ORCID: https://orcid.org/0000-0001-7838-3097)
- Viviènne Verweij
- Christa de Ruiter
- Ayla Franco
Institutions
- Radboud University Nijmegen (NL)
- Netherlands Organisation for Applied Scientific Research (NL)
- Radboud University Medical Center (NL)
- Radboud Institute for Molecular Life Sciences (NL)
Publication Details
- Journal
- Brain Behavior & Immunity - Health
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.bbih.2025.100991
- Citations
- 3
- Primary Topic
- Neurogenesis and neuroplasticity mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 3.96