Effect of the oral microbiota, blood metabolome, and inflammatory proteins on oral cavity cancer: A bidirectional two-sample Mendelian randomization study and mediation analysis

This study provides robust genetic evidence supporting causal roles for specific oral microbes and metabolites in OCC etiology. It offers mechanistic insights into the 'oral microbiome-host metabolism' axis, providing a basis for novel microbiome/metabolite-based biomarkers for early detection and risk assessment, and identifying potential preventative or therapeutic targets.