Rhizoma Atractylodis Macrocephalae reduces HFD-induced MAFLD in mice through activated AMPK-mediated inhibition of fatty acid synthesis
Through a combination of network pharmacology and experimental validation, we demonstrated that RAM may exert therapeutic effects on MAFLD by inhibiting lipid synthesis and activating phosphorylated AMPK pathways.
Authors
- Yuge Zhou (ORCID: https://orcid.org/0000-0002-1687-5552)
- Rundong Zhang (ORCID: https://orcid.org/0000-0002-1719-1961)
- Fang Wang (ORCID: https://orcid.org/0000-0003-3505-524X)
- Xiaoni Kong (ORCID: https://orcid.org/0000-0002-1406-051X)
- Liu Yang (ORCID: https://orcid.org/0000-0003-4450-8642)
- Ke Zheng (ORCID: https://orcid.org/0009-0009-1231-8941)
- Yunchang Xin (ORCID: https://orcid.org/0000-0003-3864-4090)
- Jiacheng Lin (ORCID: https://orcid.org/0000-0002-1921-7408)
- Xuehua Sun
- Weifan Huang
Institutions
- Anhui Medical University (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Shuguang Hospital (CN)
Publication Details
- Journal
- Liver Research
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.livres.2025.04.004
- Primary Topic
- Liver Disease Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00