Role for the liver X receptor agonist 22‐ketositosterol in preventing disease progression in an Alzheimer's disease mouse model
Diet supplementation with 22-ketositosterol prevented the decline in spatial memory of APPswePS1ΔE9 mice. Our data suggest therapeutic benefits of 22-ketositosterol possibly by enhancing cholesterol efflux and mitigating inflammatory responses, without inducing hepatosteatosis or hypertriglyceridemia.
Authors
- Maura Marinozzi (ORCID: https://orcid.org/0000-0001-5994-9390)
- Johan W. Jonker (ORCID: https://orcid.org/0000-0002-3919-5437)
- Lorenzo Pontini (ORCID: https://orcid.org/0000-0003-4766-0578)
- Leonie van Vark‐van der Zee (ORCID: https://orcid.org/0009-0008-7660-3330)
- Folkert Kuipers (ORCID: https://orcid.org/0000-0003-2518-737X)
- Frank Leijten
- Nikita Martens (ORCID: https://orcid.org/0000-0001-6382-3379)
- Gardi Voortman
- Silvia Friedrichs
- Albert Gerding (ORCID: https://orcid.org/0000-0002-6004-2398)
- Dieter Lütjohann (ORCID: https://orcid.org/0000-0002-7941-8308)
- Tim Vanmierlo (ORCID: https://orcid.org/0000-0003-2912-0578)
- Na Zhan (ORCID: https://orcid.org/0000-0002-9043-2768)
- Marcella Palumbo (ORCID: https://orcid.org/0000-0002-9512-6671)
- Monique T. Mulder
- Sammie C. Yam
Institutions
- University of Parma (IT)
- University Medical Center Groningen (NL)
- University of Groningen (NL)
- University of Perugia (IT)
- University Hospital Bonn (DE)
- Erasmus MC (NL)
- Maastricht University (NL)
- Ocean University of China (CN)
- Hasselt University (BE)
Publication Details
- Journal
- British Journal of Pharmacology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1111/bph.70031
- Citations
- 2
- Primary Topic
- Cholesterol and Lipid Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- Alzheimer Forschung Initiative
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek
- Alzheimer Nederland