A membrane-penetrative COF-based nanoplatform for intracellular bacterial pathogen eradication across diverse niches
A COF-based therapeutic nanoplatform has been developed that can be transported to intracellular bacteria-located regions in the host cells, where ultrasound irradiation triggered ROS generation, membrane-penetrative NO release, and the production of highly reactive peroxynitrite (ONOO<sup>-</sup>), enabling effective bacteria eradication across diverse niches.
Authors
- Yue Sun (ORCID: https://orcid.org/0000-0001-6116-7435)
- Jiadai Yi
- Jinsong Ren (ORCID: https://orcid.org/0000-0002-7506-627X)
- Xiaogang Qu (ORCID: https://orcid.org/0000-0003-2868-3205)
- Huan Wang (ORCID: https://orcid.org/0000-0001-9464-2474)
- Yanjie Zhang (ORCID: https://orcid.org/0000-0003-1639-7914)
- Yuxi Fang (ORCID: https://orcid.org/0009-0000-5019-1413)
Institutions
- University of Science and Technology of China (CN)
- Chinese Academy of Sciences (CN)
- Changchun Institute of Applied Chemistry (CN)
Publication Details
- Journal
- Chemical Communications
- Published
- 2025-01-01
- DOI
- https://doi.org/10.1039/d5cc01091h
- Citations
- 1
- Primary Topic
- Atomic and Subatomic Physics Research
- Type
- article
- Field-Weighted Citation Impact
- 1.25