Copper-Catalyzed C–B(sp<sup>3</sup>) Bond Formation through the Intermediacy of Cu–B(sp<sup>3</sup>) Complex
The vast majority of transition metal (TM) catalyzed borylative transformations rely on TM-B(sp<sup>2</sup>) complexes. Contrastingly, the chemistry of TM-B(sp<sup>3</sup>) species and their potential in catalytic borylation remain surprisingly underdeveloped, due probably to the lack of suitable boron(sp<sup>3</sup>) reagents. Herein, we employ our recently developed sp<sup>2</sup>-sp<sup>3</sup> diboron reagent to successfully enable a copper-catalyzed hydroboration of allenes for C-B(sp<sup>3</sup>) bond formation. A comprehensive mechanistic study, including the isolation and structural characterization of a Cu-B(sp<sup>3</sup>) complex, substantiates the presence of a Cu-B(sp<sup>3</sup>) intermediate in the catalytic cycle.
Authors
- Linlin Wu (ORCID: https://orcid.org/0000-0002-7657-4559)
- Stephen Lam (ORCID: https://orcid.org/0000-0002-3964-1492)
- Hairong Lyu (ORCID: https://orcid.org/0000-0002-0476-0352)
- Zhanqiang Ye (ORCID: https://orcid.org/0000-0002-6651-0375)
- Chun Yin Kwok
Institutions
- Central South University (CN)
- Chinese University of Hong Kong (HK)
- Interface (United States) (US)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1021/jacs.5c00974
- Citations
- 12
- Primary Topic
- Catalytic Cross-Coupling Reactions
- Type
- article
- Field-Weighted Citation Impact
- 11.23