Urinary peptide signature distinguishes autosomal recessive polycystic kidney disease from other causes of chronic kidney disease
We determined a urinary peptide signature that identifies paediatric patients with ARPKD with high precision among a population of children with CKD. Knowledge of the identity of the underlying peptides offers a novel starting point for discussion of possible pathophysiological processes involved in ARPKD.
Authors
- Justyna Siwy (ORCID: https://orcid.org/0000-0003-1407-2534)
- Joost P. Schanstra (ORCID: https://orcid.org/0000-0002-7471-372X)
- Daryl J. McLeod (ORCID: https://orcid.org/0000-0002-1027-2953)
- Oliver Groß (ORCID: https://orcid.org/0000-0002-8390-8852)
- Franz Schaefer (ORCID: https://orcid.org/0000-0001-7564-9937)
- Claudia Dafinger
- Max C. Liebau (ORCID: https://orcid.org/0000-0003-0494-9080)
- Julie Klein (ORCID: https://orcid.org/0000-0002-3279-0559)
- Bénédicte Buffin‐Meyer (ORCID: https://orcid.org/0000-0002-4805-1558)
- Kathrin Burgmaier (ORCID: https://orcid.org/0000-0001-9787-1096)
- Stéphane Decramer (ORCID: https://orcid.org/0000-0001-6984-762X)
- Jan Boeckhaus (ORCID: https://orcid.org/0009-0006-2021-9255)
- Brian Becknell (ORCID: https://orcid.org/0000-0002-2750-4415)
Institutions
- Nationwide Children's Hospital (US)
- Inserm (FR)
- Université Fédérale de Toulouse Midi-Pyrénées (FR)
- University of Cologne (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- University Medical Center (US)
- Mosaiques Diagnostics and Therapeutics (Germany) (DE)
- Institut des Maladies Métaboliques et Cardiovasculaires (FR)
- University Hospital Cologne (DE)
- Deggendorf Institute of Technology (DE)
Publication Details
- Journal
- Clinical Kidney Journal
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1093/ckj/sfaf093
- Citations
- 3
- Primary Topic
- Genetic and Kidney Cyst Diseases
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Universität zu Köln
- European Rare Kidney Disease Reference Network