Optimisation of the cultured ELISpot/Fluorospot technique for the selective investigation of SARS-CoV-2 reactive central memory T cells
This work advances the methodology for investigating T-cell immunity, particularly in the context of SARS-CoV-2, and emphasises the balance between enhancing specific cognate central memory responses while limiting non-specific activation.
Authors
- Kirsty Wilson (ORCID: https://orcid.org/0000-0001-7679-9611)
- Peter Richmond (ORCID: https://orcid.org/0000-0001-7562-7228)
- Monica D. Prakash (ORCID: https://orcid.org/0000-0002-2814-7560)
- Katie L. Flanagan (ORCID: https://orcid.org/0000-0002-1575-1953)
- Vasso Apostolopoulos (ORCID: https://orcid.org/0000-0001-6788-2771)
- Charlie McLeod (ORCID: https://orcid.org/0000-0002-3197-7493)
- Magdalena Plebanski (ORCID: https://orcid.org/0000-0001-6889-3667)
- Joshuah Fialho (ORCID: https://orcid.org/0000-0002-9498-6899)
- Georgia Goodchild (ORCID: https://orcid.org/0000-0001-9845-9570)
- Jack R. Jerome
Institutions
- The University of Sydney (AU)
- University of Tasmania (AU)
- Translational Research Institute (AU)
- The Royal Melbourne Hospital (AU)
- The Kids Research Institute Australia (AU)
- The University of Western Australia (AU)
- Launceston General Hospital (AU)
- Princess Margaret Hospital for Children (AU)
- Clifford Craig Foundation (AU)
- Perth Children's Hospital
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1547220
- Citations
- 2
- Primary Topic
- SARS-CoV-2 and COVID-19 Research
- Type
- article
- Field-Weighted Citation Impact
- 2.79
Funders
- RMIT University