Changes of brain structure and structural covariance networks in Parkinson’s disease with different sides of onset
In patients with LPD, reductions in CSA observed in the right PCUN, right SMG, left IPL, and left LING may be associated with cognitive impairments and hallucinations among non-motor symptoms of PD. Additionally, the SCNs of LPD and RPD patients show significant differences in global topology, but regional node characteristics do not reflect lateralization differences. These findings offer new insights into the mechanisms of symptom lateralization in PD from the perspective of brain regional structure and network topology.
Authors
- Tao Xu (ORCID: https://orcid.org/0000-0003-0433-2611)
- Wenchao Duan (ORCID: https://orcid.org/0000-0002-8163-603X)
- Zijuan Ma (ORCID: https://orcid.org/0000-0003-2260-1862)
- H. Liu (ORCID: https://orcid.org/0000-0002-2872-3089)
- Xueyan Qin
- Lianling Li
- Pengfei Yang (ORCID: https://orcid.org/0000-0002-6154-3602)
- Zhenyu Zhang (ORCID: https://orcid.org/0000-0001-8985-7083)
- Yinhui Yu (ORCID: https://orcid.org/0000-0003-1424-7250)
- Fangang Meng (ORCID: https://orcid.org/0000-0002-8577-6443)
- Siyu Zhou (ORCID: https://orcid.org/0009-0005-9277-6432)
- Yuchen Ji (ORCID: https://orcid.org/0000-0002-4828-5338)
- M. Zhang (ORCID: https://orcid.org/0000-0002-5408-7389)
- Z. Y. Deng (ORCID: https://orcid.org/0009-0005-5662-3113)
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- Capital Medical University (CN)
- Beijing Tian Tan Hospital (CN)
- Beijing Institute of Neurosurgery (CN)
- First Affiliated Hospital of Zhengzhou University (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fnagi.2025.1564754
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.39