Antifungal susceptibility and clinical efficacy of chlorhexidine combined with topical ophthalmic medications against Fusarium species isolated from corneal samples
Natamycin combined with chlorhexidine and voriconazole combined with chlorhexidine exhibited enhancement of antifungal activity against <i>Fusarium</i> spp. during in vitro sensitivity tests. The findings of this study provide valuable guidance for establishing the epidemiological cutoff and clinical MIC values for <i>Fusarium</i> spp. This study paves the way for future multicenter studies on the treatment of FK with natamycin and chlorhexidine.
Authors
- Min Ho Kang (ORCID: https://orcid.org/0000-0003-1366-8942)
- Liang Qingfeng
- Yuxuan Wu (ORCID: https://orcid.org/0000-0002-9155-9883)
- Xizhan Xu (ORCID: https://orcid.org/0000-0003-0777-7659)
- Zhiqun Wang (ORCID: https://orcid.org/0000-0001-9608-0962)
- Xinxin Lü (ORCID: https://orcid.org/0000-0002-4870-3632)
- Yang Zhang (ORCID: https://orcid.org/0000-0003-1011-3001)
- Kexin Chen (ORCID: https://orcid.org/0000-0003-4248-7681)
- Qingquan Shi (ORCID: https://orcid.org/0000-0002-2094-6958)
- Man Zhou (ORCID: https://orcid.org/0000-0002-7928-5509)
Institutions
- Beijing Tongren Hospital (CN)
- Capital Medical University (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fcimb.2025.1532289
- Citations
- 3
- Primary Topic
- Ocular Infections and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 5.12
Funders
- National Key Research and Development Program of China