Carbapenem treatment options for metallo-beta-lactamase: drug screening and dose optimization of meropenem-based combinations against NDM- or IMP-producing Klebsiella pneumoniae
Meropenem in combination with fosfomycin or colistin was an effective choice for MBL-KP. The combination regimen and dosage optimization should be assessed based on not only the type of enzyme but also the specific value of minimum inhibitory concentration (MIC).
Authors
- J. Zeng (ORCID: https://orcid.org/0000-0002-3903-0157)
- Yun Cai (ORCID: https://orcid.org/0000-0001-6687-9984)
- Xiaoming Cui (ORCID: https://orcid.org/0009-0000-1315-7865)
- Haoyue Che
- Liuhan Dong
- Rui Wang (ORCID: https://orcid.org/0000-0003-3825-3620)
- Bo Hu (ORCID: https://orcid.org/0000-0002-9070-1331)
- Jiyong Yang (ORCID: https://orcid.org/0000-0002-1194-175X)
Institutions
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fmicb.2025.1490372
- Citations
- 1
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.59
Funders
- General Hospital of People’s Liberation Army
- National Outstanding Youth Science Fund Project of National Natural Science Foundation of China
- China National Funds for Distinguished Young Scientists