Acute and subacute toxicity evaluation of ZhenzhuXiaoji decoction in preclinical models: implications for safe clinical use
Treatment with ZZXJD at standard therapeutic dosage did not produce acute or subacute toxic effects on liver or kidney functions <i>in vivo</i>, suggesting its safety for continued use in cancer treatment. However, reversible abnormalities in liver and kidney function markers were observed at higher doses. Thus, regular monitoring of liver and kidney functions is recommended during clinical use, especially when higher doses are employed.
Authors
- Yang Sun (ORCID: https://orcid.org/0000-0003-1425-0089)
- Songzhe Li (ORCID: https://orcid.org/0009-0000-8519-8113)
- Bao‐Long Li (ORCID: https://orcid.org/0000-0003-1510-0162)
- Lingyun Cai
- Yue Sun (ORCID: https://orcid.org/0000-0002-4228-5855)
- Shuchang Bao
Institutions
- Heilongjiang University of Chinese Medicine (CN)
- Nanjing Municipal Center for Disease Control And Prevention (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fphar.2025.1554732
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China