Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag

Immune thrombocytopenia (ITP) is a rare hematologic disorder characterized by low platelet counts due to an immune-mediated destruction of platelets. While corticosteroids, intravenous immunoglobulin (IVIG) are the mainstays of treatment, a subset of patients may remain refractory to these therapies. Here, we present a case of a 6-year-old girl diagnosed with refractory ITP, who failed to respond to standard therapies but showed a remarkable clinical improvement with avatrombopag, a thrombopoietin receptor agonist.

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Journal
Frontiers in Immunology
Published
2025-04-15
DOI
https://doi.org/10.3389/fimmu.2025.1576053
Primary Topic
Platelet Disorders and Treatments
Type
article
Field-Weighted Citation Impact
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article

Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag

Aniello Russo, Nicole Santoro, Daniela Onofrillo, Mauro Di Ianni et al.
Frontiers in Immunology
Platelet Disorders and Treatments
article

Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag

Aniello Russo, Nicole Santoro, Daniela Onofrillo, Mauro Di Ianni, Antonella Sau, Gianfranco Di Prinzio
article en

Abstract

Immune thrombocytopenia (ITP) is a rare hematologic disorder characterized by low platelet counts due to an immune-mediated destruction of platelets. While corticosteroids, intravenous immunoglobulin (IVIG) are the mainstays of treatment, a subset of patients may remain refractory to these therapies. Here, we present a case of a 6-year-old girl diagnosed with refractory ITP, who failed to respond to standard therapies but showed a remarkable clinical improvement with avatrombopag, a thrombopoietin receptor agonist.

Frontiers in ImmunologyVol. 16
University of Chieti-Pescara (IT), Ospedale di Santo Spirito (IT)
Good health and well-being
Openalex Percentile: Top 90%
Platelet Disorders and Treatments
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