Case Report: A case of pediatric persistent refractory ITP responsive to avatrombopag
Immune thrombocytopenia (ITP) is a rare hematologic disorder characterized by low platelet counts due to an immune-mediated destruction of platelets. While corticosteroids, intravenous immunoglobulin (IVIG) are the mainstays of treatment, a subset of patients may remain refractory to these therapies. Here, we present a case of a 6-year-old girl diagnosed with refractory ITP, who failed to respond to standard therapies but showed a remarkable clinical improvement with avatrombopag, a thrombopoietin receptor agonist.
Authors
- Aniello Russo (ORCID: https://orcid.org/0000-0003-3651-8146)
- Nicole Santoro (ORCID: https://orcid.org/0000-0001-5705-8084)
- Daniela Onofrillo
- Mauro Di Ianni (ORCID: https://orcid.org/0000-0002-6701-4023)
- Antonella Sau
- Gianfranco Di Prinzio
Institutions
- University of Chieti-Pescara (IT)
- Ospedale di Santo Spirito (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fimmu.2025.1576053
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00