Long-term exposure to high-altitude hypoxic environments reduces blood pressure by inhibiting the renin-angiotensin system in rats
Long-term hypoxic exposure at high-altitude reduces blood pressure in SHR rats, which may be attributed to a combination of cardiac functional compensation failure, vascular remodelling, and simultaneous inhibition of the ACE-Ang II-AT1R and ACE2-Ang1-7-MasR axes.
Authors
- Junbo Zhu (ORCID: https://orcid.org/0000-0002-3786-6727)
- Mengyue Wang (ORCID: https://orcid.org/0000-0001-9106-6125)
- Ning Qu (ORCID: https://orcid.org/0000-0001-9323-4292)
- Delong Duo (ORCID: https://orcid.org/0000-0001-5597-6690)
- Xiangyang Li (ORCID: https://orcid.org/0000-0001-6494-2388)
- Xuejun Wang (ORCID: https://orcid.org/0000-0001-5895-936X)
Institutions
- Qinghai University (CN)
- Qinghai Red Cross Hospital (CN)
- Qinghai Tibetan Hospital (CN)
Publication Details
- Journal
- Frontiers in Physiology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fphys.2025.1565147
- Citations
- 3
- Primary Topic
- High Altitude and Hypoxia
- Type
- article
- Field-Weighted Citation Impact
- 5.45