Transcriptome sequencing revealed that lymph node metastasis of papillary thyroid microcarcinoma is associated with high THBS4 expression and PDGFRA+ cancer-associated fibroblasts
This study's findings indicate that THBS4 could be a potential biomarker for predicting the risk of lymph node metastasis in papillary thyroid microcarcinoma, thus potentially guiding more personalized surgical interventions. Further validation in larger patient cohorts and the interactions between THBS4 and CAFs are necessary.
Authors
- Li Wan
- Jie Zheng (ORCID: https://orcid.org/0000-0002-6446-2250)
- Yi Lin (ORCID: https://orcid.org/0000-0001-8644-614X)
- Jianmin Li (ORCID: https://orcid.org/0000-0002-2827-2185)
- Rui Zhao (ORCID: https://orcid.org/0000-0002-4772-3981)
- Yiyi Ma (ORCID: https://orcid.org/0000-0002-3609-8877)
- Ling Hu (ORCID: https://orcid.org/0000-0001-8253-4441)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fonc.2025.1536063
- Citations
- 1
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 1.29
Funders
- Wenzhou Medical University