Prenatal methadone exposure produces functional and molecular alterations in the basolateral amygdala and decreased voluntary ethanol intake in female, but not male offspring
Collectively, this study identified impairments in emotion and reward processing, in addition to alterations in synaptic function and gene expression in the BLA of females with a history of PME, supporting previous findings from our lab demonstrating that female offspring are more sensitive to the long-term effects of PME.
Authors
- Elena I. Varlinskaya (ORCID: https://orcid.org/0000-0003-0797-1814)
- Marvin R. Diaz (ORCID: https://orcid.org/0000-0002-6786-5709)
- Meredith E. Gamble (ORCID: https://orcid.org/0000-0003-1442-7796)
- Terrence Deak (ORCID: https://orcid.org/0000-0002-1514-4600)
- María del Pilar del Fidalgo Montero
- David Silberstein
Institutions
- Binghamton University (US)
Publication Details
- Journal
- Frontiers in Behavioral Neuroscience
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fnbeh.2025.1570951
- Citations
- 2
- Primary Topic
- Prenatal Substance Exposure Effects
- Type
- article
- Field-Weighted Citation Impact
- 6.99