Lung Tissue Extracellular Vesicles-Mediated Delivery of miR-128-3p as a Novel Mechanism of Acute Lung Inflammation
We identified extracellular vesicles (EVs) enriched in lung tissues from septic ALI mice, selectively carrying miRNAs including miR-128-3p. In vivo administration of these EVs exacerbated pulmonary inflammation by expanding M1 macrophage populations, while in vitro experiments demonstrated EV-mediated miR-128-3p delivery to macrophages stimulated TNF-α and IL-6 production. Mechanistically, miR-128-3p promoted macrophage proliferation and inflammatory responses by targeting Rab20.
Authors
- Xiaoping Zhu (ORCID: https://orcid.org/0000-0002-6295-2985)
- Wei Deng (ORCID: https://orcid.org/0000-0002-7392-8083)
- Kejian Qian (ORCID: https://orcid.org/0000-0002-0742-0409)
- Ping Hu (ORCID: https://orcid.org/0009-0008-1506-7319)
- H Li (ORCID: https://orcid.org/0000-0001-5668-4526)
- Fen Liu (ORCID: https://orcid.org/0009-0001-5216-3931)
Institutions
- Nanchang University (CN)
- First Affiliated Hospital of Nanchang University (CN)
Publication Details
- Journal
- International Journal of Nanomedicine
- Published
- 2025-04-01
- DOI
- https://doi.org/10.2147/ijn.s510241
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81