The novel brain penetrant ataxia-telangiectasia mutated inhibitor WSD0628 provides robust radiosensitization of brain tumor patient-derived xenografts

Collectively, these results suggest a promising role for WSD0628 in combination with RT in brain tumors and provide the rationale for an ongoing Phase 0/1A clinical trial testing this combination in recurrent GBM.

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Publication Details

Journal
Neuro-Oncology
Published
2025-04-15
DOI
https://doi.org/10.1093/neuonc/noaf102
Citations
5
Primary Topic
Glioma Diagnosis and Treatment
Type
article
Field-Weighted Citation Impact
8.13
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article

The novel brain penetrant ataxia-telangiectasia mutated inhibitor WSD0628 provides robust radiosensitization of brain tumor patient-derived xenografts

Katrina K. Bakken, Lauren L. Ott, Jann Nagina Sarkaria, Lateef A Odukoya et al.
5 citations
Neuro-Oncology
Glioma Diagnosis and Treatment
8.13
article

The novel brain penetrant ataxia-telangiectasia mutated inhibitor WSD0628 provides robust radiosensitization of brain tumor patient-derived xenografts

Katrina K. Bakken, Lauren L. Ott, Jann Nagina Sarkaria, Lateef A Odukoya, Zhiyi Xue, Rachael A. Vaubel, William F. Elmquist, Matthew Kosel, Danielle M. Burgenske, Jeanette E. Eckel‐Passow, Lily Liu, Shiv K. Gupta, Brett L. Carlson, Sneha Rathi, Paul A. Decker, William G. Breen, Sonja Dragojevic, Sonia Jain, Ann C. Mladek, D. Garcia, Zeng Hu, Wei Zhong
article en
5 citations

Abstract

Collectively, these results suggest a promising role for WSD0628 in combination with RT in brain tumors and provide the rationale for an ongoing Phase 0/1A clinical trial testing this combination in recurrent GBM.

Neuro-OncologyVol. 27(9)
University of Minnesota (US), Mayo Clinic (US), University of Minnesota System (US), Ondine Biopharma (United States) (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US), Qilu Hospital of Shandong University (CN)
Good health and well-being
Openalex Percentile: Top 3%
Glioma Diagnosis and Treatment
8.13
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