The novel brain penetrant ataxia-telangiectasia mutated inhibitor WSD0628 provides robust radiosensitization of brain tumor patient-derived xenografts
Collectively, these results suggest a promising role for WSD0628 in combination with RT in brain tumors and provide the rationale for an ongoing Phase 0/1A clinical trial testing this combination in recurrent GBM.
Authors
- Katrina K. Bakken (ORCID: https://orcid.org/0009-0009-8900-0077)
- Lauren L. Ott (ORCID: https://orcid.org/0009-0009-9109-317X)
- Jann Nagina Sarkaria (ORCID: https://orcid.org/0000-0001-7489-4885)
- Lateef A Odukoya (ORCID: https://orcid.org/0000-0001-9213-2235)
- Zhiyi Xue
- Rachael A. Vaubel (ORCID: https://orcid.org/0000-0001-8842-5975)
- William F. Elmquist (ORCID: https://orcid.org/0000-0002-7478-3429)
- Matthew Kosel (ORCID: https://orcid.org/0009-0008-5787-0134)
- Danielle M. Burgenske (ORCID: https://orcid.org/0000-0003-0014-5579)
- Jeanette E. Eckel‐Passow (ORCID: https://orcid.org/0000-0002-6113-1114)
- Lily Liu
- Shiv K. Gupta (ORCID: https://orcid.org/0000-0002-9107-9935)
- Brett L. Carlson (ORCID: https://orcid.org/0000-0003-2460-3079)
- Sneha Rathi (ORCID: https://orcid.org/0000-0002-4631-0085)
- Paul A. Decker (ORCID: https://orcid.org/0000-0002-3756-4227)
- William G. Breen (ORCID: https://orcid.org/0000-0001-8039-2398)
- Sonja Dragojevic (ORCID: https://orcid.org/0000-0003-3971-8530)
- Sonia Jain (ORCID: https://orcid.org/0000-0002-3728-6642)
- Ann C. Mladek (ORCID: https://orcid.org/0000-0002-0508-6531)
- D. Garcia (ORCID: https://orcid.org/0009-0005-4656-3401)
- Zeng Hu (ORCID: https://orcid.org/0009-0002-2618-4912)
- Wei Zhong (ORCID: https://orcid.org/0000-0003-2917-4832)
Institutions
- University of Minnesota (US)
- Mayo Clinic (US)
- University of Minnesota System (US)
- Ondine Biopharma (United States) (US)
- Mayo Clinic in Arizona (US)
- Mayo Clinic in Florida (US)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Neuro-Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1093/neuonc/noaf102
- Citations
- 5
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 8.13