Haploidentical, matched-related, and matched-unrelated hematopoietic cell transplant for acute leukemias in the early years of haploidentical transplant implementation in a developing country with a large unrelated donor registry
Only survival bias can explain these findings in CR2+, suggesting some high-risk MUD patients, in which HCT timing is crucial, may not achieve HCT. Alternative donors were associated with higher non-relapse mortality, while PTCy-based Haplo offered the best protection against chronic graft-versus-host disease. Our study suggests Haplo and MUD are acceptable options for patients lacking MSD in developing countries like ours.
Authors
- Vaneuza Araújo Moreira Funke (ORCID: https://orcid.org/0000-0002-2122-7277)
- Carmem Bonfim (ORCID: https://orcid.org/0000-0003-0343-2610)
- Fernando Barroso Duarte (ORCID: https://orcid.org/0000-0001-5170-695X)
- Mary E.D. Flowers (ORCID: https://orcid.org/0000-0003-1631-0911)
- Jayr Schmidt Filho (ORCID: https://orcid.org/0000-0001-8212-1620)
- Ricardo Chiattone (ORCID: https://orcid.org/0000-0001-7341-8502)
- Rodolfo Daniel de Almeida Soares (ORCID: https://orcid.org/0000-0001-5531-964X)
- Mair Pedro de Souza (ORCID: https://orcid.org/0000-0002-7411-9296)
- Phillip Scheinberg (ORCID: https://orcid.org/0000-0002-9047-4538)
- Mariana Nassif Kerbauy (ORCID: https://orcid.org/0000-0002-4441-9212)
- Anderson João Simione (ORCID: https://orcid.org/0000-0002-6939-906X)
- Shahrukh K. Hashmi (ORCID: https://orcid.org/0000-0002-8914-7927)
- Antônio Vaz de Macedo (ORCID: https://orcid.org/0000-0002-7633-8839)
- Carmen Silvia Vieitas Vergueiro
- Gustavo Bettarello (ORCID: https://orcid.org/0009-0004-2104-961X)
- Adriana Seber (ORCID: https://orcid.org/0000-0003-4578-9423)
- Nelson Hamerschlak (ORCID: https://orcid.org/0000-0002-5140-5310)
- Wael Saber (ORCID: https://orcid.org/0000-0002-6544-5815)
- Jinalben Patel (ORCID: https://orcid.org/0009-0002-9301-9941)
- Cláudia Cáceres Astigarraga
- Décio Lerner (ORCID: https://orcid.org/0000-0003-1104-591X)
- Leonardo Javier Arcuri (ORCID: https://orcid.org/0000-0002-9673-1945)
- Maria Cristina Martins de Almeida Macedo (ORCID: https://orcid.org/0000-0002-6105-9968)
- Liane Esteves Daudt (ORCID: https://orcid.org/0000-0001-9495-6932)
- Victor Gottardello Zecchin (ORCID: https://orcid.org/0000-0002-9778-3480)
- Marcelo C. Pasquini (ORCID: https://orcid.org/0000-0003-1579-2293)
- Tatiana Dias Marconi Monteiro
- Afonso Celso Vigorito
- Vergílio R. Colturato
- Eduardo Paton
- Yana Augusta Novis Zogbi
Institutions
- Medical College of Wisconsin (US)
- Hospital Israelita Albert Einstein (BR)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.3389/fonc.2025.1584631
- Citations
- 1
- Primary Topic
- Hematopoietic Stem Cell Transplantation
- Type
- article
- Field-Weighted Citation Impact
- 1.77