Longitudinal Analysis of Calcium and Parathyroid Hormone Levels in Normocalcemic Patients Following Total Thyroidectomy

Purpose: To investigate the relationship between pre-and post-operative calcium and parathyroid hormone (PTH) levels in normocalcemic patients undergoing total thyroidectomy. Methods:We included all adult patients who are undergoing complete thyroidectomy, collecting data on serum calcium, PTH, vitamin D, and thyroid-stimulating hormone (TSH) levels before the operation as well as six months after the operation.We excluded those patients with significant changes in vitamin D or on supplementation.Statistical analysis used paired T-tests to measure alterations in biochemical indicators.Results: Out of 23 patients included, it was seen that although corrected calcium and PTH levels decreased significantly, everyone stayed within the normocalcemic range six months after thyroidectomy.There were no notable changes in vitamin D and TSH levels.This implies an impact of total thyroidectomy on parathyroid gland function. Conclusion:This study shows a noticeable drop in calcium and PTH levels after thyroidectomy.Although these changes are not enough to reach clinical manifestations, it is considered of statistical significance.These findings indicate the need for individualized management and close monitoring to avoid long-term complications.More investigation should concentrate on the probable significance of these biochemistry alterations within clinical settings, along with creating methods for intervening accurately.