Integration of Nanotechnology with Quinazolines in the Medical Field

Abstract Quinazoline, a magical and attractive compound, has a wide range of biological and pharmaceutical applications in the form of derivative compounds. The remarkable biological properties such as antibacterial, antifungal, anti‐inflammatory, antimalarial, antiviral, and other unique features of quinazolines are mainly responsible for its novel structures, materials, and devices in medicinal chemistry and nanotechnology. This article describes the role of quinazolines in nanotechnology, their advantages and disadvantages, medical case studies, and future developments. In DNA nanotechnology, one of the quinazoline derivatives acts as a substitute for thymine in nucleic acid complexes. Drug dexrazoxane is a quinazoline derivative widely used as a cardio‐protective agent in nanomechanics. The syntheses of biologically active quinazoline derivatives using nanocatalysts have shown efficient chemical transformations. Quinazolines, being antifungal agents, are widely used in humans and plants as nano‐engineered medicines with low toxicity. Nowadays, new quinazoline‐based compounds are being synthesized as possible drugs of anticancer effectiveness against bladder cancer, breast cancer, head and neck cancer, lung cancer, and many more anticancer therapies. Controlled release of quinazolines towards antibacterial action can be achieved by changing the pH < 7 or pH > 7 and with the solid support of using metal clusters and appropriate organic ligands.