Asthma treatment response modified by fine particulate matter, nitrogen dioxide, and ozone among Black children: A reanalysis of the AsthmaNet Best African American Response to Asthma Drugs trial
Residential high NO<sub>2</sub> exposure may significantly attenuate the efficacy of ICS+LABA therapy on lung function in Black children. These findings suggest the need to consider environmental factors in clinical trials and asthma management strategies.
Authors
- Susan J. Kunselman
- Michael T. Young (ORCID: https://orcid.org/0000-0002-8566-6308)
- Julian Solway (ORCID: https://orcid.org/0000-0002-0898-8530)
- Lizbeth Gomez (ORCID: https://orcid.org/0000-0003-3725-7531)
- Stephen C. Lazarus (ORCID: https://orcid.org/0000-0002-3230-0556)
- Leslie A. McClure (ORCID: https://orcid.org/0000-0002-2465-6739)
- Anne M. Fitzpatrick (ORCID: https://orcid.org/0000-0002-2933-5926)
- Wanda Phipatanakul (ORCID: https://orcid.org/0000-0001-8639-0473)
- Steven R. White (ORCID: https://orcid.org/0000-0003-3496-0707)
- Sharmilee Maria Nyenhuis (ORCID: https://orcid.org/0000-0002-7381-9733)
- Fernando Holguín (ORCID: https://orcid.org/0000-0003-0979-8234)
- Edward T. Naureckas (ORCID: https://orcid.org/0000-0002-3171-8176)
- Joel D. Kaufman (ORCID: https://orcid.org/0000-0003-4174-9037)
- Ellen Kinnee (ORCID: https://orcid.org/0000-0002-6719-2591)
- Jane E. Clougherty (ORCID: https://orcid.org/0000-0002-9911-1565)
- Usama Bilal (ORCID: https://orcid.org/0000-0002-9868-7773)
- David T. Mauger (ORCID: https://orcid.org/0000-0002-4663-5285)
- Michael E. Wechsler
Institutions
- Boston Children's Hospital (US)
- Pennsylvania State University (US)
- Emory University (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- University of Washington (US)
- University of California System (US)
- National Jewish Health (US)
- University of Chicago (US)
- Public Health Department (IN)
- Boston Children's Museum (US)
- Department of Public Health (MM)
- Pulmonary and Critical Care Associates (US)
- Saint Louis University (US)
- Drexel University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Allergy and Clinical Immunology
- Published
- 2025-04-15
- DOI
- https://doi.org/10.1016/j.jaci.2025.04.009
- Citations
- 3
- Primary Topic
- Air Quality and Health Impacts
- Type
- article
- Field-Weighted Citation Impact
- 3.60
Funders
- National Heart, Lung, and Blood Institute