Circulating Food Allergen‐Specific Antibodies, Beyond <scp>IgG4</scp>, Are Elevated in Eosinophilic Esophagitis
Our findings reveal distinct antibody profiles in EoE plasma, with elevated IgG and IgA subclasses beyond IgG4, highlighting a complex immune response to food allergens. Differential antibody responses support their clinical relevance in dietary management strategies, while the absence of allergen-specific B cells in circulation likely restricts antibody production to the inflamed oesophagus. Future research should explore whether these antibody profiles can guide personalised treatment and novel therapeutic targets in EoE.
Authors
- Alex Straumann (ORCID: https://orcid.org/0000-0002-1428-6404)
- Manal Bel Imam (ORCID: https://orcid.org/0000-0002-7352-7204)
- Alain Schoepfer (ORCID: https://orcid.org/0000-0001-6341-9536)
- Mübeccel Akdiş (ORCID: https://orcid.org/0000-0003-0554-9943)
- P. Schreiner (ORCID: https://orcid.org/0009-0001-8037-4242)
- Luc Biedermann (ORCID: https://orcid.org/0000-0003-0824-4125)
- Lotte Bach Larsen
- Nina Aagaard Poulsen
- Lacin Cevhertas (ORCID: https://orcid.org/0000-0003-2287-3569)
- Sophieke Lems (ORCID: https://orcid.org/0009-0002-4119-9565)
- Andrea Kreienbühl (ORCID: https://orcid.org/0009-0002-3564-639X)
- Sayuri Iwasaki
- Willem van de Veen (ORCID: https://orcid.org/0000-0001-9951-6688)
- Patrick Westermann (ORCID: https://orcid.org/0000-0003-2894-6140)
Institutions
- University of Zurich (CH)
- Aarhus University (DK)
- Centre Hospitalier Universitaire Vaudois (CH)
- University Hospital of Zurich (CH)
- Medical University of Vienna (AT)
- University of Lausanne (CH)
Publication Details
- Journal
- Clinical & Experimental Allergy
- Published
- 2025-04-14
- DOI
- https://doi.org/10.1111/cea.70055
- Citations
- 3
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 6.02
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Promedica Stiftung